Effect of Gestational Diabetes on Serum Leptin during Pregnancy and Postpartum Period: Effect of GDM on S. Leptin

Jazib Andleeb; Faiza Mehboob; Sana Javaid; Mudassar Ali; Muhammad Imran Khan; Qurat-ul-Ain

doi:10.37978/tijfs.v5i1.315

Authors

Jazib Andleeb Physiology Department, CMH Institute of Medical Sciences, Bahawalpur, Pakistan Author
Faiza Mehboob Anatomy Department, Multan Medical & Dental College, Multan, Pakistan Author
Sana Javaid Physiology Department, Sharif Medical & Dental College, Lahore, Pakista Author
Mudassar Ali Physiology Department, Rashid Latif Medical College, Lahore, Pakistan Author
Muhammad Imran Khan Physiology Department, DG Khan Medical College, Dera Ghazi Khan, Pakistan Author
Qurat-ul-Ain Biochemistry Department, University College of Medical & Dentistry, Lahore, Pakistan Author

DOI:

https://doi.org/10.37978/tijfs.v5i1.315

Keywords:

Serum Leptin, Serum Insulin, Pregnancy, HOMA index, Gestational diabetes mellitus

Abstract

Background: Gestational diabetes mellitus (GDM) is associated with marked increase in insulin resistance. The objective of study is to determine the relation of gestational diabetes with serum leptin and serum insulin levels during pregnancy and postpartum period.

Methods: This case control study conducted on total ninety samples that include cases and controls taken after 24 weeks of gestation. The case sample included 40 pregnant women with GDM and 10 women with GDM at postpartum stage. The control sample included 30 normal pregnant women with no GDM and 10 normal women at postpartum. Fasting serum leptin and fasting serum insulin were measured by ELISA. HOMA index was calculated by fasting serum insulin and fasting blood glucose.

Results: Serum leptin (30.89 ± 1.35), serum insulin (27.67 ± 1.32) and HOMA index (8.33 ± 0.53) significantly high in gestational diabetic women than normal pregnant (p<0.05) during pregnancy. However, after delivery of fetus, serum leptin, serum insulin and HOMA index in gestational diabetics significantly decreased compared to during gestation period. Hence a positive correlation of GDM was determined against serum leptin and HOMA index.

Conclusion: Serum leptin level is raised in GDM which has a positive correlation with insulin resistance. This study finds that the serum leptin levels may use as a marker to early screen and diagnose Gestational diabetes.